NMX offers client-based services for discovering hits and leads for future drugs.
Services can range from a complete solutions such as "gene to leads" or focused projects such as:
Production and purification of disease target.
Biophysical screening for hits.
Medicinal chemistry for leads.
NMX has specialty services in fragment-based drug discovery incuding our in-house fragment libraries (1H, 19F) and commercial libaries.
Emphasis on toolbox of NMR strategies to ensure delivery of quality hits and leads.
Combinations of assays and strategies can be tailored or invented to address client needs.
NEW! uNMR now offers same-day NMR data acquisition services.
- Protein production and purification using different vectors
- Optimisation of procedures
- Screening of buffer conditions for assay and NMR experiments
- Molecular Biology
Biophysics / NMR:
- NMR fragment-based screening
- Binding studies by NMR
- Protein assignments
- 3D structure determinations
- Binding site determinations
- Modeling of ligand-protein complexes
- NMR consulting and collaborations
- Primary structure verifications
- Atropisomer chirality
- Metabolite ID and monitoring
- Aggregation studies by NMR
- Compound library analyses
- Focused SAR follow-up
- SAR by cataloging