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BIOPHYSICS

The Many Facets of NMR

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LIGAND BINDING STUDIES

NMR binding studies ranging from a single experiment to a consensus-based approach combining various experiments. Compounds are ranked by scores to guide medicinal chemistry efforts.

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1H LIGAND-DETECTION

Allows for a more exhaustive evaluation of binding, sample integrity, compound concentration and binding epitope.

19F LIGAND-DETECTION

The highly sensitive fluorine atom allows for fast, background-free detection of a wide range of binding events.

PROTEIN-DETECTED NMR

Higher affinity compounds can sometimes be missed by ligand-observed techniques. Monitoring protein fingerprints helps bridge the gap between ligand-detected NMR and other biophysical techniques, while keeping track of protein integrity.

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