The Many Facets of NMR
LIGAND BINDING STUDIES
NMR binding studies ranging from a single experiment to a consensus-based approach combining various experiments. Compounds are ranked by scores to guide medicinal chemistry efforts.
Allows for a more exhaustive evaluation of binding, sample integrity, compound concentration and binding epitope.
The highly sensitive fluorine atom allows for fast, background-free detection of a wide range of binding events.
Higher affinity compounds can sometimes be missed by ligand-observed techniques. Monitoring protein fingerprints helps bridge the gap between ligand-detected NMR and other biophysical techniques, while keeping track of protein integrity.