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Publications

NMX stays at the cutting edge of drug discovery research by constantly expanding and redefining what can be achieved by our biochemical and biophysical tools of choice.

This section features a selection of recently published developments.

NMR spectroscopy can help accelerate antiviral drug discovery programs

Steven R. LaPlante a b c, Pascale Coric c, Serge Bouaziz c, Tanos C.C. França a

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Microbes and Infection

Evaluation of expanded 2-aminobenzothiazole library as inhibitors of a model histidine kinase and virulence suppressors in Pseudomonas aeruginosa

Conrad A. Fihn a, Hannah K. Lembke b, Jeffrey Gaulin c, Patricia Bouchard d, Alex R. Villarreal e, Mitchell R. Penningroth e, Kathryn K. Crone f, Grace A. Vogt e, Adam J. Gilbertsen e, Yann Ayotte d, Luciana Coutinho de Oliveira d, Michael H. Serrano-Wu g, Nathalie Drouin ,Deborah T. Hung c, Ryan C. Hunter e, Erin E. Carlson a b f

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Bioorganic Chemistry, Volume 153, December 2024, 107840

Robust Strategy for Hit-to-Lead Discovery: NMR for SAR

Sacha T. Larda, Yann Ayotte, Maria M. Denk, Paul Coote, Gregory Heffron, David Bendahan, Fatma Shahout, Nicolas Girard, Mustapha Iddir, Patricia Bouchard, Francois Bilodeau, Simon Woo, Luc J. Farmer, and Steven R. LaPlante

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Journal of Medicinal Chemistry (2023)

Jumping from Fragment to Drug via Smart Scaffolds.

Dr. Majid D. Farahani, Dr. Tanos C. C. França, Dr. Saba Alapour, Fatma Shahout, Dr. Richard Boulon, Dr. Mustapha Iddir, Michael Maddalena, Dr. Yann Ayotte, Prof. Steven R. LaPlante

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ChemMedChem (2022)

Fragment-Based Phenotypic Lead Discovery To Identify New Drug Seeds That Target Infectious Diseases

Yann Ayotte, Eve Bernet, François Bilodeau, Mena Cimino, Dominic Gagnon, Marthe Lebughe,
Maxime Mistretta, Paul Ogadinma, Sarah-Lisa Ouali, Aïssatou Aïcha Sow, Laurent Chatel-Chaix,
Albert Descoteaux, Giulia Manina, Dave Richard, Frédéric Veyrier, and Steven R. LaPlante

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ACS Chem. Biol. (2021)

Probing the free-state solution behavior of drugs and their tendencies to self-associate into nano-entities.

LaPlante, S.R.; Roux, V.; Shahout, F.; Laplante, G.; Woo, S.; Ayotte, Y.; Denk, M.; Larda, S.T.

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Nature Protocols (2021).

NMR-based Approaches to the Study of GPCRs and GPCR-ligand Interactions.

Pandey, A.; Larda, S.T.; LaPlante, S.R.; Prosser, R.S.

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GPCRs Structure, Function, and Drug Discovery (2020): 65-80.

Exposing Small-molecule Nano-entities By An NMR Relaxation Assay.

Ayotte,Y.; Marando,V.M.; Vaillancourt,L.; Bouchard,P.; Heffron,G.; Coote,P.W.; Larda,S.T.; LaPlante,S.R.

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J. Med. Chem. (2019), 62; 17: 7885-7896.

Fragment-Based Phenotypic Lead Discovery: Cell-Based Assay to Target Leishmaniasis.

Ayotte Y, Bilodeau F, Descoteaux A, LaPlante SR.

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ChemMedChem. (2018) 18;13(14):1377-1386.

NMR strategies to support medicinal chemistry workflows for primary structure determination.

Oguadinma, P.; Bilodeau, F.; LaPlante, S.R.

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Bioorganic & Medicinal Chemistry Letters, (2017) 27: 242-247.

Resurgence of Phenotypic Screening for Discovering Drug Leads.

Ayotte, Y & LaPlante, S.R.

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EC Microbiology 7.3, (2017): 80-82.

The Rise of Academia-Pharma Partnerships for Discovering New Chemical Matter for Future Drugs.

LaPlante, S; Bilodeau, F.

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EC Microbiology 4.5 (2016): 756-758.