Brief Info - January 2025
- Stéphanie Clouston
- Jun 17
- 3 min read
Happy New Year from the NMX team! ✨ We greatly look forward to working with you throughout 2025 to help accelerate your drug discovery projects. Our expert team of scientists are always prepared to problem-solve alongside our clients, using their experience and know-how to tackle any problem along the FBLD pipeline.
FBLD Workflow ______________________________________
At NMX, our workflow and methodologies have been optimized to overcome common pitfalls within the FBLD process, which often results in costly and time-consuming limitations. Between the stages of “initial screening” and “confirmed weak binders”, common problems arise which make this process challenging: issues with physico-chemical properties, poor solution behavior resulting in false positives/negatives, high concentration requirements, among others.
NMX’s multifaceted, cyclic approach re-envisions the linear workflow of classic FBLD. We comprehensively study the target and ligand systems early-on to understand the relevant properties and behavior, ultimately avoiding many of the sneaky issues previously mentioned. This allows for quicker progress towards successful compound screening and analoging by NMR, ultimately establishing affinity rankings and structure-activity-relationships, which are crucial pieces of information when moving into bio-assay testing and determining strong binders for leads.
_________ NMR Optimization and Crystallography Services
We understand that many clients struggle with the demands of producing NMR-suitable samples, often having to work with expensive deuterated buffers, being unable to prepare samples in the necessary buffer conditions or unable to remove components critical for sample stability. Recently, NMX has dedicated significant efforts to enable our fragment-based NMR methodologies to work entirely with non-deuterated components, increasing sample viability while improving signal resolution, allowing us to pass the savings directly back to our clients!
Common buffers and components such as HEPES, Tris, PEG, and urea have been successfully optimized for use in their protonated forms with our improved solvent suppression protocols, while more are in-development. NMX can additionally customize protocols for client needs if required buffer conditions fall outside of the currently optimized non-deuterated systems.
Along with continually improving NMR methodologies and offerings for our clients, NMX is excited to offer crystallography services to help elucidate structural and binding site information for client targets. Crystal growth, data analysis, and data refinement can now be completed in-house by our experts, providing greater insights at various points of the FBLD process, particularly in the fragment growth stages within the med chem cycle.
Many new services, offerings, and collaborations are in the works at NMX, so stay tuned for these updates throughout 2025!
Wondering how NMX's optimized workflow and in-house expertise could help progress your research goals? Meet with us to discuss your project priorities, budget, and more.
Contact us today: ✉️ nmx@nmxresearch.com | 📞 (438)-391-1684
NMX Events _________________________________________
SLAS2025 International Conference and Exhibition
The NMX team will be attending the SLAS2025 International Conference & Exhibition, taking place on January 25th-29th, 2025 in San Diego, CA.
SLAS 2025 is centered around curiosity and innovation, concepts crucial in moving science forward. NMX is excited to support this initiative, coming together with other world-class researchers, startups, suppliers, and technology innovators!
🔎 Find us at Booth #2849 to discuss how NMX can help you achieve your drug discovery goals.
⏰ Busy schedule during the conference? Email us ahead of time to set up a private meeting: nmx@nmxresearch.com
See you soon in San Diego!
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NMX Research and Solutions, Inc. 500, Boulevard Cartier Ouest, Suite 6000 Laval, Québec, Canada H7V 5B7
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